In Vitro Toxicology

Arista Laboratories provides basic and investigative in vitro toxicology services through the utilization of tools to study early and late genotoxic and cytotoxic effects of individual compounds and materials of varying complexity and sources (plant, animal and human tissues and specimen agrochemicals, drugs, personal care products, and natural products).

Our capabilities allow us to test products in various phases (i.e., gas, solid and liquid), and therefore we offer our services to a wide spectrum of customers that include governmental and regulatory agencies, manufacturers of tobacco products, pharmaceutical, chemical, personal and neutraceutical industries.

Services include testing to meet Health Canada’s Tobacco Reporting Regulations (HC TRR) for mutagenicity (Ames), cytotoxicity (neutral red uptake) and clastogenicity/aneugenicity (micronucleus) in particulate, vapor and whole smoke phases. Other assays include, but are not limited to, sister chromatid exchange (SCE) and COMET assays using animal or human primary or immortalized cell lines.

Mutagenicity findings are evaluated and interpreted using a proprietary VISITOX interface to the SALM statistical software program developed by scientists of the University of North Carolina (Byung Kim and Barry Margolin, Mut Res 436, 1999). This interface is available to independent researchers for the evaluation of their own data through Arista’s secure client login interface.